Genomics

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Comprehensive miRNA expression profiling in human T-cell acute lymphoblastic leukemia by small RNA-sequencing


ABSTRACT: We profiled the full miRNA expression profile of 48 T-ALL patient samples from different subtypes by means of small RNA-sequencing, identifying for the first time subtype specific miRNA signatures. In addition we also profiled T-ALL cell lines by small RNA-sequencing, recapitulating the subtype specific miRNAs. Furthermore, profiling of CD34+ and CD4+CD8+ healthy donor thymocytes identified several novel potential oncogenic miRNAs or miRNAs with a tumor suppressive role in T-ALL. With these datasets, we complement the mRNA and lncRNA T-ALL subtype specific expression signatures with miRNAs, leading to the full transcriptomic profile of T-ALL subtypes.

ORGANISM(S): Homo sapiens

PROVIDER: GSE89978 | GEO | 2017/08/10

SECONDARY ACCESSION(S): PRJNA354349

REPOSITORIES: GEO

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