Transcriptomics

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Suppression of the grainyhead transcription factor 2 gene (GRHL2) inhibits the proliferation, migration, invasion and mediates cell cycle arrest of ovarian cancer cells


ABSTRACT: Previously, we have identified cytosolic form of the grainyhead transcription factor 2 gene (GRHL2) as notably hypomethylated in low-malignant potential (LMP) and high-grade (HG) serous epithelial ovarian tumors, compared to normal ovarian tissues. Here we show that GRHL2 is strongly overexpressed in both LMP and HG serous EOC tumors, thus suggesting that epigenetic mechanisms might be implicated in GRHL2 overexpression in serous epithelial ovarian cancer (EOC). Knockdown of the GRHL2 expression in EOC cells led to sharp decrease of cell proliferation and induced G1-phase cell cycle arrest. Additionally, GRHL2 suppression significantly inhibited EOC cell migration and invasion. Gene expression profiling and consecutive network and pathway analyses confirmed these findings, as numerous genes and pathways known previously to be implicated in ovarian tumorigenesis, including EOC tumor invasion and metastasis, were found to be downregulated upon BCAT1 suppression, while some tumor suppressor genes were induced. Taken together, our data are indicative for a strong oncogenic potential of the GRHL2 gene in advanced EOC and identify this transaminase as a novel EOC biomarker and putative EOC therapeutic target.

ORGANISM(S): Homo sapiens

PROVIDER: GSE90132 | GEO | 2017/04/21

SECONDARY ACCESSION(S): PRJNA354516

REPOSITORIES: GEO

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