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CD54+BP1+YFP- bone marrow stromal cells from IL7 reporter mice

ABSTRACT: Hematopoiesis in adult mammals involves cognate interactions between developing hematopoietic cells and bone marrow stromal cell niches. SCF and CXCL12 play key roles in the maintenance of HSC, while early B cell differentiation requires CXCL12 and IL7. In this study, we characterized mouse BM stromal cells expressing IL7 by performing a transcriptomic analysis. We found that SCF, CXCL12 and IL7 were co-expressed by a unique peri-sinusoidal stromal cell subset.

ORGANISM(S): Mus musculus

PROVIDER: GSE90584 | GEO | 2019/03/01

REPOSITORIES: GEO

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