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Recognition of RNA N6-methyadenosine by IGF2BP proteins Enhances mRNA Stability

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE90686 | GEO | 2018/03/15

REPOSITORIES: GEO

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Recognition of RNA N6-methyadenosine by IGF2BP proteins Enhances mRNA Stability

Project description:Recognition of RNA N6-methyadenosine by IGF2BP proteins Enhances mRNA Stability

| PRJNA355382 | ENA

Recognition of RNA N<sup>6</sup>-methyladenosine by IGF2BP proteins enhances mRNA stability and translation.

Project description:N6-methyladenosine (m6A) is the most prevalent modification in eukaryotic messenger RNAs (mRNAs) and is interpreted by its readers, such as YTH domain-containing proteins, to regulate mRNA fate. Here, we report the insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs; including IGF2BP1/2/3) as a distinct family of m6A readers that target thousands of mRNA transcripts through recognizing the consensus GG(m6A)C sequence. In contrast to the mRNA-decay-promoting function of YTH domain-containing family protein 2, IGF2BPs promote the stability and storage of their target mRNAs (for example, MYC) in an m6A-dependent manner under normal and stress conditions and therefore affect gene expression output. Moreover, the K homology domains of IGF2BPs are required for their recognition of m6A and are critical for their oncogenic functions. Thus, our work reveals a different facet of the m6A-reading process that promotes mRNA stability and translation, and highlights the functional importance of IGF2BPs as m6A readers in post-transcriptional gene regulation and cancer biology.

| S-EPMC5826585 | biostudies-literature

IGF2BP proteins Enhance mRNA stability

Project description:To evaluate the effect of IGF2BPs on mRNA stability and gene expression output, we conducted RNA-seq in individual IGF2BP knockdown and control HepG2 cells with or without actinomycin D treatment. Our RNA-seq and RNA stability profiling revealed that IGF2BPs were involved in RNA stability regulation and contributed to the stabilization of the transcriptome.

2018-03-15 | GSE90684 | GEO

Identification of mRNAs bound and regulated by human LIN28 proteins and molecular requirements for RNA recognition

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2013-02-26 | E-GEOD-44616 | biostudies-arrayexpress

Engineering of a histone-recognition domain in Dnmt3a alters the epigenetic landscape of ESCs revealing changes in lineage specification and chromosomal stability

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2015-06-22 | E-GEOD-57577 | biostudies-arrayexpress

Mammalian TRIM71 as repressor of mRNAs that inhibits translation and affects mRNA stability

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2013-01-22 | E-GEOD-37714 | biostudies-arrayexpress

Circular RNAs affect mRNA stability

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-11-28 | GSE240092 | GEO

Systematic identification of 3'UTR regulatory elements in activity-dependent mRNA stability in hippocampal neurons

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2014-03-12 | E-GEOD-55781 | biostudies-arrayexpress

N6-methyladenosine-mediated structural changes are associated with transcript cleavage and stability in Arabidopsis

Project description:This SuperSeries is composed of the SubSeries listed below.

2018-11-09 | GSE108852 | GEO

Imp/IGF2BP levels modulate individual neural stem cell growth and division through myc mRNA stability.

Project description:The numerous neurons and glia that form the brain originate from tightly controlled growth and division of neural stem cells, regulated systemically by important known stem cell-extrinsic signals. However, the cell-intrinsic mechanisms that control the distinctive proliferation rates of individual neural stem cells are unknown. Here, we show that the size and division rates of Drosophila neural stem cells (neuroblasts) are controlled by the highly conserved RNA binding protein Imp (IGF2BP), via one of its top binding targets in the brain, myc mRNA. We show that Imp stabilises myc mRNA leading to increased Myc protein levels, larger neuroblasts, and faster division rates. Declining Imp levels throughout development limit myc mRNA stability to restrain neuroblast growth and division, and heterogeneous Imp expression correlates with myc mRNA stability between individual neuroblasts in the brain. We propose that Imp-dependent regulation of myc mRNA stability fine-tunes individual neural stem cell proliferation rates.

| S-EPMC7025822 | biostudies-literature

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