Transcriptomics

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Guanabenz effect on activated GM-CSF DCs


ABSTRACT: Guanabenz is an FDA approved drug for hypertension. It has been shown also to be an inhibitor of GADD34, the stress-inducible cofactor of PP1. GADD34 has been shown to play a key role in controlling cytokine production in MEFs and dendritic cells. A microarray-based mRNA transcription analysis was used to compare the transcriptional response of GM-CSF DCs, activated with poly I:C or Proteus mirabilis, in presence or absence of 50µM Guanabenz.

ORGANISM(S): Mus musculus

PROVIDER: GSE90831 | GEO | 2017/08/15

SECONDARY ACCESSION(S): PRJNA356070

REPOSITORIES: GEO

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