Gene-expression profiling in desmoplastic small round cell tumors
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ABSTRACT: The study provides evidence that DSRCTs are characterised by a high degree of plasticity governed by the MErT/hybrid-partial EMT/EMT process and that, within this three-way switching, the hybrid/partial and MErT classes are also enriched in stemness. The expression of miRNA-21 in all three classes indicates pluripotency as an additional trait of DSRCT cells. These findings are consistent with either the broad histological spectrum of DSRCTs or their poor response to treatments, including tailored treatments against AR-positive DSRCTs. The study also demonstrates that DSRCTs carry a PD-L1 signature corresponding to “immunological ignorance” and highlights the fact that this signature is closely histotype-related and immuno-context-dependent. Finally, the results show that ISLR/Meflin, a further marker of pluripotency, is co-expressed with PDGFRα in DSRCT cells, albeit at a low level and that, in line with the first report concerning PDGFRα, their expression correlates with desmoplasia.
ORGANISM(S): Homo sapiens
PROVIDER: GSE90904 | GEO | 2017/08/15
SECONDARY ACCESSION(S): PRJNA356299
REPOSITORIES: GEO
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