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Primary nasal epithelium exposed to house dust mite extract shows activated expression in allergics

ABSTRACT: Response to allergen was studied in epithelial cells derived from allergic pantients and from healthy controls. Cells were cultured after isolation from a nasal biopsy. Cells were exposed to Housed dust mite or vessel (saline) Microarray data was analysed using bioinformatics and biostaistics. We conclude that a marked difference in basal expression and in response to hous dust mite exists Keywords: cellular response to allergen

ORGANISM(S): Homo sapiens

PROVIDER: GSE9150 | GEO | 2007/11/10

SECONDARY ACCESSION(S): PRJNA102699

REPOSITORIES: GEO

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Transcription profiling of human primary nasal epithelium exposed to house dust mite extract shows activated expression in allergics

Project description:Response to allergen was studied in epithelial cells derived from allergic pantients and from healthy controls. Cells were cultured after isolation from a nasal biopsy. Cells were exposed to Housed dust mite or vessel (saline); Microarray data was analysed using bioinformatics and biostaistics. We conclude that a marked difference in basal expression and in response to hous dust mite exists Experiment Overall Design: We used 5 monotypic house dust mite allergic patients and 5 non-allergic healthy controls, the cells obtained from the biopsies were cultured in two wells, for two different conditions.

2008-06-16 | E-GEOD-9150 | biostudies-arrayexpress

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