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A CpG island methylator phenotype in acute myeloid leukemia independent of IDH mutations and associated with a favorable outcome

ABSTRACT: Acute myeloid leukemia (AML) causes the most leukemia-related deaths in the United States. Although genetic changes are assessed in the clinic for risk stratification, current classifications are imperfect and epigenetic determinants of AML curability remain poorly understood. To address this gap in knowledge we performed genome-wide DNA methylation analysis using the next-generation sequencing-based Digital Restriction Enzyme Analysis of Methylation (DREAM) assay on 96 clinical AML samples, and 35 normal peripheral blood controls. We identified patterns of aberrant DNA hypermethylation in distinct subsets of cases, and these patterns were associated with unique clinical, and genetic features. Validation an extension of these findings was performed using 194 samples from The Cancer Genome Atlas (TCGA).

ORGANISM(S): Homo sapiens

PROVIDER: GSE92254 | GEO | 2017/01/19

SECONDARY ACCESSION(S): PRJNA357043

REPOSITORIES: GEO

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