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PPARD is a critical inhibitor of cartilage growth in external ears [ChIP-Seq]

ABSTRACT: In this study, we uncover the molecular mechanism that PPARD transactive-deficient pigs have large-eared feature. Evidently from this work, PPARD plays a vital role on inhibiting cartilage growth by regulating the transcription of critical genes for chondrogenesis in ligand dependent manner; the activation of sPPARD speeds up apoptosis in CSPCs, terminal differentiation of chondroblasts and matrix degradation in auricular cartilage. The transactive-deficient PPARD has not the capability to slow down cartilage growth and consequently causes that ear size of carried animals increases at a high growth rate. As the role of PPARD in cartilage is similar in pigs, mice and humans, and since cartilage development is well-conserved in animals, our data helps to better understanding of cartilage development and treatment of cartilage-related diseases.

ORGANISM(S): Sus scrofa

PROVIDER: GSE92370 | GEO | 2017/06/09

SECONDARY ACCESSION(S): PRJNA357364

REPOSITORIES: GEO

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PPARD is a critical inhibitor of cartilage growth in external ears [RNA-Seq]

Project description:In this study, we uncover the molecular mechanism that PPARD transactive-deficient pigs have large-eared feature. Evidently from this work, PPARD plays a vital role on inhibiting cartilage growth by regulating the transcription of critical genes for chondrogenesis in ligand dependent manner; the activation of sPPARD speeds up apoptosis in CSPCs, terminal differentiation of chondroblasts and matrix degradation in auricular cartilage. The transactive-deficient PPARD has not the capability to slow down cartilage growth and consequently causes that ear size of carried animals increases at a high growth rate. As the role of PPARD in cartilage is similar in pigs, mice and humans, and since cartilage development is well-conserved in animals, our data helps to better understanding of cartilage development and treatment of cartilage-related diseases.

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