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Expression data from progesterone receptor knockout versus heterozygous mouse ovaries: granulosa cells

ABSTRACT: Ovulation requires sequential molecular events and structural remodeling in the ovarian follicle for the successful release of a mature oocyte capable of being fertilised. Critical to this process is progesterone receptor (PGR), a transcription factor highly yet transiently expressed in granulosa cells of preovulatory follicles. Progesterone receptor knockout (PRKO) mice are anovulatory, with a specific and complete defect in follicle rupture. Therefore, this model was used to examine the critical molecular and biochemical mechanisms necessary for successful ovulation. We used microarrays to identify putative PGR-regulated genes in granulosa cells at a time when PGR expression is maximal (eCG + 8h hCG) and the preovulatory follicle is undergoing the final changes necessary for successful ovulation.

ORGANISM(S): Mus musculus

PROVIDER: GSE92437 | GEO | 2018/04/20

REPOSITORIES: GEO

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Expression data from progesterone receptor knockout versus heterozygous mouse ovaries: cumulus oocyte complexes

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