Effects of exosomes from T lymphocytes of NOD mice on pancreatic islet-cell gene expression

ABSTRACT: During Type 1 diabetes development, T lymphocytes infiltrate pancreatic islets and induce the destruction of the insulin-producing cells within the islets, the beta-cells. T lymphocytes are known to secrete pro-inflammatory cytokines but also exosomes that could contribute to the mechanisms leading to beta-cell death. In this project, we wanted to investigate the effect of exosomes released from T lymphocytes on beta-cell gene expression.

ORGANISM(S): Mus musculus

PROVIDER: GSE92439 | GEO | 2018/09/11

REPOSITORIES: GEO