Transcriptomics

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Analysis of parent-of-origin bias in gene expression levels


ABSTRACT: In order to study parent-of-origin effects on gene expression, we performed RNAseq analysis (100bp single end reads) of 165 children who formed part of mother/father/child trios where genotype data was available from the HapMap and/or 1000 Genomes Projects. Based on phased genotypes at heterozygous SNP positions, we generated allelic counts for expression of the maternal and paternal alleles in each individual. This analysis reveals significant bias in the expression of the parental alleles for dozens of genes, including both previously known and novel imprinted transcripts.

ORGANISM(S): Homo sapiens

PROVIDER: GSE92521 | GEO | 2018/06/15

REPOSITORIES: GEO

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