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Molecular effects on individual and combined toxicity of OTA and CTN against human embryonic kidney 293 cells

ABSTRACT: We report the transcriptome and miRNAome of human embryonic kidney 293 cells upon the administration of ochratoxin A (OTA) and citrinin (CTN), to compare the individual and combined toxicity of these two mycotoxins. We identified largely differentially expressed miRNAs and corresponding genes, and the correlations between miRNAs and their target genes associated with apoptotic signaling were furthermore analyzed by pmi-RB-REPORT luciferase assay system. We concluded that hsa-miR-1-3p plays an essential role in promoting OTA and CTN-induced renal cytotoxicity.

ORGANISM(S): Homo sapiens

PROVIDER: GSE93148 | GEO | 2017/12/31

SECONDARY ACCESSION(S): PRJNA360136

REPOSITORIES: GEO

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