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The role and mechanism of erythrocyte invasion by Francisella tularensis

ABSTRACT: Francisella tularensis, is an extremely virulent bacterium that can be transmitted naturally by blood sucking arthropods. During mammalian infection, F. tularensis infects numerous types of host cells, including erythrocytes. As erythrocytes do not undergo phagocytosis or endocytosis, it remains unknown how F. tularensis invades these cells. Furthermore, the consequence of inhabiting the intracellular space of red blood cells has not been determined. Here, we provide evidence indicating that residing within an erythrocyte enhances the ability of F. tularensis to colonize ticks following a blood meal.

ORGANISM(S): Francisella tularensis

PROVIDER: GSE93233 | GEO | 2017/05/24

SECONDARY ACCESSION(S): PRJNA360386

REPOSITORIES: GEO

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