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RNA Sequencing Reveals Regulation of Marginal Zone B-Cell Differentiation by MicroRNA-146a

ABSTRACT: Splenocytes were FACS-sorted from Wild-type and Mir146a-/- mice to isolate specific B-cell developmental stages. Utilizing high-throughput sequencing, we comparatively analyzed developmental stage-specific splenic B cell transcriptomes, including Transitional-1 (T1), Transitional-2 (T2), Marginal zone (MZ) and Follicular (FO) in both Wild-type and Mir146a-/- B cells. Two replicates of each developmental stage were submitted for high-throughput sequencing.

ORGANISM(S): Mus musculus

PROVIDER: GSE93252 | GEO | 2017/01/15

SECONDARY ACCESSION(S): PRJNA360425

REPOSITORIES: GEO

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