Transcriptomics

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Transcriptome analysis of p16/p21-dependent monocytic myeloid-derived suppressor cells accumulation.


ABSTRACT: p16 and p21 act as tumor suppressors through induction of cellular senescence. However, senescence-independent roles of these CDK inhibitors are not known. To identify the mechanism responsible for the failure of Mo-MDSCs (monocytic myeloid-derived suppressor cells) infiltration into tumor allografts in p16/p21-double knockout (DKO) mice, we searched for chemokine receptors that were highly expressed in Mo- but not PMN-MDSCs (polymorphonuclear myeloid-derived suppressor cells) and were downregulated in p16/p21-DKO as compared to WT Mo-MDSCs. Ccr2, Ccr5, and Cx3cr1 were identified by RNA-seq analysis.

ORGANISM(S): Mus musculus

PROVIDER: GSE93359 | GEO | 2018/02/13

REPOSITORIES: GEO

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