Gingerol treatment with 400 ppm for 2 h
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ABSTRACT:
ORGANISM(S): Saccharomyces cerevisiae
PROVIDER: GSE9359 | GEO | 2007/11/01
SECONDARY ACCESSION(S): PRJNA103055
REPOSITORIES: GEO
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Project description:The number and type of synthetic chemicals that are being produced worldwide continues to increase significantly. While these industrial chemicals provide numerous benefits, there is no doubt that some have potential to damage the environment and health. Toxicity must be evaluated and use must be carefully controlled and monitored in order to minimize potential damage. DNA microarray technology has become an important new technique in toxicology. We are using the yeast Saccharomyces cerevisiae as a model organism for toxicological study because it is a simple, fast-growing eukaryote that has been thoroughly characterized. In order to evaluate toxicity by newly synthesized or mixture chemicals, toxicity-induced gene expression alteration profiles by known chemicals should be collected. In our study, cells need to be exposed with same experimental cellular condition, semi lethal (IC50), respectively. In the case of chloroacetaldehyde (CAS; 107-20-0), the exposure dose was decided as 25 ppm by growth curve with continuously diluted exposure. Chloroacetaldehyde is one of the toxic gases and vapors. This substrate is suspected to be respiratory toxicant and skin or sense organ toxicant. Keywords: stress response
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2008-01-15 | GSE10102 | GEO
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2008-01-15 | GSE10101 | GEO
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Project description:The number and type of synthetic chemicals that are being produced worldwide continues to increase significantly. While these industrial chemicals provide numerous benefits, there is no doubt that some have potential to damage the environment and health. Toxicity must be evaluated and use must be carefully controlled and monitored in order to minimize potential damage. DNA microarray technology has become an important new technique in toxicology. We are using the yeast Saccharomyces cerevisiae as a model organism for toxicological study because it is a simple, fast-growing eukaryote that has been thoroughly characterized. In order to evaluate toxicity by newly synthesized or mixture chemicals, toxicity-induced gene expression alteration profiles by known chemicals should be collected. In our study, cells need to be exposed with same experimental cellular condition, semi lethal (IC50), respectively. In the case of supiculisporic acid, one of bio-surfactants, the exposure dose was decided as 0.16 % by growth curve with continuously diluted exposure. Keywords: stress response
2007-11-01 | GSE9462 | GEO
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