Transcriptomics

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In vivo analysis of injury sites presenting full or attenuated pericyte-derived scarring after spinal cord injury (SCI)


ABSTRACT: A subpopulation of pericytes expressing the Glast-CreERT2 transgene (Type A pericytes) has recently been identified as the main source of stromal scar tissue that forms after SCI. Identification of molecules associated with pericyte-derived scarring may offer new therapeutic targets to facilitate axon regeneration following central nervous system (CNS) injury. We conducted genome-wide RNA sequencing of (i) uninjured spinal cord segments and (ii) lesion sites presenting full or attenuated pericyte-derived scarring 14 days after SCI.

ORGANISM(S): Mus musculus

PROVIDER: GSE93976 | GEO | 2018/02/27

REPOSITORIES: GEO

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