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Transcriptome response of the Streptococcus pneumoniae D39 wild-type to Naicin

ABSTRACT: Transcriptome Comparison of the Streptococcus pneumoniae D39 wild-type grown in CDM with 0 mM to 10mM Niacin

ORGANISM(S): Streptococcus pneumoniae D39

PROVIDER: GSE94513 | GEO | 2017/02/24

SECONDARY ACCESSION(S): PRJNA371174

REPOSITORIES: GEO

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Transcriptional response of Streptococcus pneumoniae D39 to Zinc

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Streptococcus pneumoniae D39 wild-type grown in CDM+10 mM arginine compared to D39 wild type grown in CDM + 0.05 mM arginine

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Transcriptome response of the Streptococcus pneumoniae D39 wild-type to NADH

Project description:The objective of this comparison was to identify the impact of NADH on the transcriptome of Streptococcus pneumoniae D39. Transcriptome comparison of the D39 wild-type grown in chemically-defined medium (CDM) with 0 mg/ml NADH to 0.5 mg/ml NADH revealed elevated expression of various genes/operons (adhB1, fba, hemH, rex, gapN, nirC, pncB, gap, adhE, and adhB2) involved in the transport and biosynthesis of niacin. In this study, we investigated the transcriptomic response of Streptococcus pneumoniae D39 to NADH. Transcriptome comparison of the D39 wild-type grown in chemically-defined medium (CDM) with 0 mg/ml NADH to 0.5 mg/ml NADH revealed elevated expression of various genes/operons (adhB1, fba, hemH, rex, gapN, nirC, pncB, gap, adhE, and adhB2) involved in the transport and biosynthesis of niacin. Microarray results were further confirmed by β-galactosidase assays. Promoter-lacZ fusions assays and microarray studies showed that the transcriptional regulator, Rex acts as a transcriptional repressor of a number of genes/operons (adhB1, fba, hemH, rex, gapN, nirC, pncB, gap, adhE, and adhB2) involved in niacin uptake and biosynthesis in the presence of NADH. The putative operator site of Rex in the promoter regions of Rex-regulated genes is predicted and confirmed by promoter mutational experiments.

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argR1 mutant compared to D39 wild-type in Streptococcus pneumoniae in CDM + 10 mM arginine

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ahrC mutant compared to D39 wild-type in Streptococcus pneumoniae in CDM + 10 mM arginine

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