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Identification of MELK-regulated genes in prostate cancer cells using next-generation sequencing

ABSTRACT: A cross-species analysis identified MELK as a potential therapeutic target in prostate cancer. To further elucidate the functional role of MELK in prostate cancer cells, we aimed to identify MELK-regulated genes. C4-2b cells were either treated with a small-molecule MELK inhibitor (OTSSP167), or transfected with siRNAs targeting MELK. Differentially expressed genes were identified using next-generation sequencing. Our results demonstrate that MELK promotes the expression of genes associated with tumour progression in prostate cancer cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE94570 | GEO | 2018/02/05

REPOSITORIES: GEO

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