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Elucidation of roles of Nr4a nuclear orphan receptors and Foxp3 in thymic Treg cell development

ABSTRACT: Both Nr4a family nuclear orphan receptors and Foxp3 had been revealed to be crucial transcription factors in Treg cell development. In this study, to reveal their roles in a Treg cell developmental transcriptional programs, we compared transcriptomes among wild-type conventional CD4 T (Tconv) cells, wild-type Treg cells, Nr4a-triple-knockout (Nr4a-TKO) Treg precursor (preTreg) cells, and Foxp3-KO preTreg cells by microarray.

ORGANISM(S): Mus musculus

PROVIDER: GSE94727 | GEO | 2017/02/10

SECONDARY ACCESSION(S): PRJNA373860

REPOSITORIES: GEO

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Gene expression profiles of wild type and Nr4a-triple knockout (Nr4a-TKO) Tnaive and iTreg 3 h

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Involvement of Nr4a in a Treg-specific transcriptional program and suppression of　Th2/Tfh response

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