Comparison of lncRNA and mRNA expression profile among the livers of C57BL/6J control mice, high fat diet (HFD) mice and metformin treated mice
Ontology highlight
ABSTRACT: Nonalcoholic fatty liver disease (NAFLD) is a growing worldwide epidemic and an important risk factor for the development of insulin resistance, type 2 diabetes, nonalcoholic steatohepatitis (NASH), and hepatic cellular carcinoma (HCC). Despite the prevalence of NAFLD, lifestyle interventions involving exercise and weight loss are the only accepted treatments for this disease. Over the past years, metformin has been shown to improve NAFLD in preclinical animal models. However, whether and how the long non-coding RNAs (lncRNAs) were involved in the progression of NAFLD and the mechanism of metformin treatment were not clearly understood. The aim of this study was to identify lncRNAs associated with the regulation of liver lipid metabolism after metformin treatment. We performed computational analysis of the function enrichment of the differentially expressed lncRNAs and mRNAs. Our analysis also suggested significant co-expression between hepatic lncRNAs and their predicted mRNA targets. Our analysis suggests a noticeable role in the etiology and treatment of NAFLD.
ORGANISM(S): Mus musculus
PROVIDER: GSE94790 | GEO | 2018/06/21
REPOSITORIES: GEO
ACCESS DATA