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Gene expression profiling of dsDNA-transfected reconstituted mouse embryonic fibroblasts

ABSTRACT: Analysis of dsDNA-induced innate immune response at gene expression level. The hypothesis tested in this study was that K224R mutation significantly inhibits hSTING activity. Results provide important information of the response of hSTING and its variants to cytosolic dsDNA, such as induction of type I IFN genes and proinflammatory cytokine genes.

ORGANISM(S): Mus musculus

PROVIDER: GSE94845 | GEO | 2017/02/14

SECONDARY ACCESSION(S): PRJNA374572

REPOSITORIES: GEO

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