Transcriptomics

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RAD51 Interconnects Between DNA Replication, DNA Repair and Immunity


ABSTRACT: RAD51, a multifunctional protein, plays a central role in DNA replication and homologous recombination repair, and is known to be involved in cancer development. We identified a novel role for RAD51 in innate immune response signaling. Defects in RAD51 lead to the accumulation of self-DNA in the cytoplasm, triggering a STING-mediated innate immune response after replication stress and DNA damage. Our data suggest that in addition to playing roles in homologous recombination-mediated DNA double-strand break repair and replication fork processing, RAD51 is also implicated in the suppression of innate immunity. Thus, our study reveals a previously uncharacterized role of RAD51 in initiating immune signaling, placing it at the hub of new interconnections between DNA replication, DNA repair, and immunity.

ORGANISM(S): Homo sapiens

PROVIDER: GSE95050 | GEO | 2017/02/18

SECONDARY ACCESSION(S): PRJNA375818

REPOSITORIES: GEO

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