Transcriptomics

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The role of MAGI1 (membrane-associated guanylate kinase with inverted domain structure-1) in regulating disturbed flow-induced changes of gene expression


ABSTRACT: To understand the function of MAGI1 in ECs, we isolated total RNAs from human umblical vein endothelial cells (HUVECs) transfected with control or Magi1 siRNA and transcriptionally profiled them. Ingenuity pathway Analysis (IPA) demonstrated activation of antiviral responses, including interferon signaling, without affecting NF-κB expression and inhibition of ER stress gene expression induced by the reduction of MAGI1 expression. Because activation of interferon signaling tends to increase NF-κB activation, the finding that depletion of MAGI1 promotes antiviral responses without increasing NF-κB activation is unique, suggesting that MAGI1 is an incomparable molecular switch for pro-viral and pro-inflammatory responses.

ORGANISM(S): Homo sapiens

PROVIDER: GSE95066 | GEO | 2019/05/09

REPOSITORIES: GEO

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