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BRD2 cooperates with CTCF to enforce transcriptional and architectural boundaries


ABSTRACT: BET (bromodomain and extraterminal motif) proteins are pharmacologic targets for the treatment of diverse diseases, yet the roles of individual BET family members remain unclear. We find that BRD2 colocalizes with the architectural/insulator protein CCCTC-binding factor (CTCF) genome-wide. To test a role for BRD2 in chromatin architecture we performed HiC in uninduced G1E-ER4 cells (-GATA1), and compared it to HiC in BRD2-depleted G1E-ER4 cells

ORGANISM(S): Mus musculus

PROVIDER: GSE95476 | GEO | 2017/03/31

SECONDARY ACCESSION(S): PRJNA377236

REPOSITORIES: GEO

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