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Celecoxib, Rofecoxib Chronically Treated Mice, with IL1beta, Aorta RNA-Seq

ABSTRACT: We screen for vascular off-target effects at therapeutic concentrations of celecoxib and rofecoxib using genomic approaches in a mouse model of vascular inflammatory responses. We assess whether therapeutic concentrations of celecoxib and rofecoxib might elicit distinct genomic effects in vivo in mice by comprehensive and unbiased analysis of the whole transcriptome sequencing. Drug specific differences in their expression profiles would be indicative of off-target effects.

ORGANISM(S): Mus musculus

PROVIDER: GSE95500 | GEO | 2020/02/28

REPOSITORIES: GEO

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