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Identification of differential expressed genes of JQ1 or JQ1+Bortezomib in colorectal cancer cells

ABSTRACT: The bromodomain and extra-terminal domain inhibitors (BETi) are promising epigenetic drugs for the treatment of various cancers through suppression of oncogenic transcription factors including MYC. However, only a subset of CRC cells response to BETi, suggesting an intrinsic resistance to BETi in CRC. We investigated the effect of JQ1 on cell proliferation, apoptosis, angiogenesis and MYC expression in a panel of 11 CRC cells in vitro and in vivo. JQ1-resistant CRC cells were used for the screening for the effective combination therapies with JQ1. RNA-seq of single drug or combined drugs treatment was performed to explore the mechanism of action.

ORGANISM(S): Homo sapiens

PROVIDER: GSE95513 | GEO | 2017/10/01

SECONDARY ACCESSION(S): PRJNA377308

REPOSITORIES: GEO

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SAHA, VPA and JQ1 treatment in ISOS-1

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