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ICF-specific DNMT3B dysfunction interferes with intragenic regulation of mRNA transcription and alternative splicing (RIP-seq)

ABSTRACT: We performed a transcriptomic and epigenomic study in patient-derived B-cell lines to investigate the genome-scale effects of DNMT3B dysfunction. We highlighted that altered intragenic CpG-methylation impairs multiple aspects of transcriptional regulation, like alternative TSS usage, antisense transcription and exon splicing.

ORGANISM(S): Homo sapiens

PROVIDER: GSE95744 | GEO | 2017/03/07

SECONDARY ACCESSION(S): PRJNA378323

REPOSITORIES: GEO

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Project description:This SuperSeries is composed of the SubSeries listed below.

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