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Gene expression profiles of activin-A-induced human Tr1-like regulatory T cells and T conventional cells.

ABSTRACT: The aim of our studies was to investigate the molecular mechanisms underlying the differentiation of human Tr1-like regulatory T cells by the cytokine activin-A. We employed high-throughput sequencing of the whole T cell transcriptome and characterized the transcriptional profile of activin-A-induced human Tr1-like regulatory T cells (act-A-iTr1 cells) and compared it to those of Tconventional cells (Tconv). Our studies identified novel immunoregulatory molecules/pathways involved in the differentiation and effector function of human act-A-iTr1 cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE95820 | GEO | 2017/03/21

SECONDARY ACCESSION(S): PRJNA378523

REPOSITORIES: GEO

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