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Length-independent telomere damage drives cardiomyocyte senescence

ABSTRACT: Ageing is the biggest risk factor to cardiovascular health and is associated with increased incidence of cardiovascular disease. Cellular senescence, a process driven in part by telomere shortening has been implicated in age-related cardiac dysfunction. However, the role of cellular senescence and its underlying mechanisms in slowly dividing/post-mitotic cardiomyocytes is not understood.

ORGANISM(S): Mus musculus

PROVIDER: GSE95822 | GEO | 2019/02/06

REPOSITORIES: GEO

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