Epigenetic Drift of H3K27me3 in Aging Links Glycolysis to Healthy Longevity
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ABSTRACT: We adapted ChIP-Rx method established in cells to fly tissues for quantitative ChIP-seq. We found the deposition of H3K27me3 during aging loses fidelity, resulting its propagation across the epigenome; lowering H3K27me3 by PRCs-deficiency promotes healthy lifespan by mitigating this trend. Quantitative multi-omic analysis converges on a central role of glycolysis, linking H3K27me3 dynamics to the regulation of glycolytic genes, which correspondingly rewire cellular metabolic homeostasis including energy and redox potential that impact lifespan and adult fitness.
ORGANISM(S): Drosophila melanogaster
PROVIDER: GSE96654 | GEO | 2018/06/04
REPOSITORIES: GEO
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