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Transcriptome profiling of murine aortic endothelium deleted for the transcription factor Mef2c

ABSTRACT: Laminar flow on endothelial cells in vitro activates MEF2 transcription factors to induce expression of atheroprotective genes. Here we sought to establish in vivo MEF2 functions in the endothelium through endothelial-specific deletion of Mef2c. Our results show that endothelial Mef2c regulates migration of vascular smooth muscle from the tunica media into the intima through fenestrations in the internal elastic lamina. Moreover, Mef2c regulates actin stress fiber formation in the endothelium. To investigate Mef2c-dependent targets in the endothelium, we perform transcriptome profiling on RNA isolated from the aortic endothelium with or without Mef2c deletion.

ORGANISM(S): Mus musculus

PROVIDER: GSE97089 | GEO | 2017/05/31

SECONDARY ACCESSION(S): PRJNA380653

REPOSITORIES: GEO

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