Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Trans-Generational Hormesis and the Inheritance of Aging Resistance

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Drosophila melanogaster

PROVIDER: GSE97238 | GEO | 2017/07/01

SECONDARY ACCESSION(S): PRJNA381046

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Trans-Generational Hormesis and the Inheritance of Aging Resistance [RNA-seq]

Project description:Animals respond to dietary changes by adapting their metabolism to available nutrients through insulin and insulin-like growth factor signalling. Restricting calorie intake generally extends life and health span, but Drosophila fed non-ideal sugars such as galactose are stressed and have shorter life spans. Here, we report that although these flies have shorter life spans, their offspring show significant life extension if switched to a normal sugar (glucose) diet. We define this as TGH or trans-generational hormesis, a beneficial effect that comes from a mild stress. We trace the effects to changes in stress responses in parents, ROS production, effects on lipid metabolism, and changes in chromatin and gene expression. We find that this mechanism is similar to what happens to the long lived Indy mutants on normal food, but surprisingly find that Indy is required for life span extension for galactose fed flies. Indy mutant flies grown on galactose do not live longer as do their siblings grown on glucose, rather overexpression of Indy rescues lifespan for galactose reared flies. We define a process where sugar metabolism can generate epigenetic changes that are inherited by offspring, providing a mechanism for how transgenerational nutrient sensitivities are passed on.

2017-07-01 | GSE97233 | GEO

Trans-Generational Hormesis and the Inheritance of Aging Resistance [ChIP-seq]

2017-07-01 | GSE97162 | GEO

Trans-Generational Hormesis and the Inheritance of Aging Resistance

Project description:Trans-Generational Hormesis and the Inheritance of Aging Resistance

| PRJNA381046 | ENA

Inter- and trans-generational impact of H3K4 methylation in neuronal homeostasis

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-05-23 | GSE215921 | GEO

H2A.Z inheritance during the cell cycle

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2012-11-23 | E-GEOD-41091 | biostudies-arrayexpress

Environmentally induced epigenetic transgenerational inheritance of ovarian disease

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2014-07-17 | E-GEOD-59278 | biostudies-arrayexpress

Paternally induced transgenerational inheritance of susceptibility to diabetes in mammals

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2013-01-02 | E-GEOD-43239 | biostudies-arrayexpress

Mendelian and trans-generational inheritance in hypertensive renal disease.

Project description:Familial risk in hypertensive renal disease has stimulated a search for genetic variation contributing to this risk. The current phase of population genetic studies has sought to associate genetic variation with disease in large populations by testing genotypes at a large number of common genetic variations in the genome, expecting that common genetic variants contributing to renal disease risk will be identified. These genome-wide association studies (GWAS) have been productive and are a clear technical success. It is also clear that narrowly defined loci and genes containing variation contributing to disease risk have been identified. Further extension and refinement of these GWAS are likely to extend this success. However, it is also clear that few if any variants with substantial effects accounting for the greatest part of heritability will be uncovered by GWAS. This raises an interesting biological question regarding where the remaining heritable risk may be located. One result of the progress of GWAS is likely to be a renewed interest in mechanisms by which related individuals can share and transmit traits independently of Mendelian inheritance. This paper reviews current progress in this area and considers other mechanisms by which familial aggregation of risk for renal disease may arise.

| S-EPMC3562706 | biostudies-literature

Intergenerational inheritance of trained immunity and heterologous resistance to infections

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-08-23 | GSE130327 | GEO

The Immunobiology of Aging

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2015-11-07 | E-GEOD-74786 | biostudies-arrayexpress