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Gene expression profiling of dMyc null Drosophila larvae

ABSTRACT: Myc oncoproteins are essential regulators of the growth and proliferation of mammalian cells. In Drosophila the single ortholog of Myc (dMyc), encoded by the dm gene, influences organismal size and the growth of both mitotic and endoreplicating cells. A null mutation in dm (dm4) results in attenuated endoreplication and growth arrest early in larval development. Gene expression analysis indicates that loss of dMyc leads to decreased expression of genes required for ribosome biogenesis and protein synthesis. Keywords: cDNA expression microarray, mutant analysis

ORGANISM(S): Drosophila melanogaster

PROVIDER: GSE9729 | GEO | 2008/01/22

SECONDARY ACCESSION(S): PRJNA103647

REPOSITORIES: GEO

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