Study on the mechanism of Shcisandrol A in immune function modulation in mice based on the mRNA expression profile chip

ABSTRACT: At present, with the accelerating pace of life, increase in work pressure, lack of exercise, irregularity of diet and rest, and problems of environmental pollution, people with immunodeficiency are gradually increasing in the modern population. Some Chinese herbal medicines can improve the immunity of the human body, and have less and mild side or toxic effects, so that the study on this kind of traditional Chinese medicines and its mechanism has become an urgent problem to be solved. In recent years, studies have shown that Shcisandrol A (Sch A) can regulate immune function and inhibit the inflammation of nervous system. In this study, mRNA expression profile chip was used to screen the differentially expressed genes related to the effect of Sch A on immunodepressed mice induced by cyclophosphamide (Cy), and the differentially expressed gene-telated pathways were analyzed by gene ontology function cluster analysis, and finally qPCR was applied to verify the 5 genes that might be related to the regulation of Sch A on the mice’s immune functions, to provide a theoretical basis for screening the drug targets on which Sch A could act to regulate the mice’s immune functions.

ORGANISM(S): Mus musculus

PROVIDER: GSE97316 | GEO | 2020/04/03

REPOSITORIES: GEO