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LaminB and H3K9me2 ChIP-seq During Mouse Cardiogenesis

ABSTRACT: Progenitor cells require coordinated expression of lineage-specific programs, and the nuclear lamina has emerged as an important scaffold for organizing chromatin in many cell types. These ChIP-seq experiments accompany a study focused on defining nuclear organization changes during cardiac development. Specifically, these experiments map the binding sites of LaminB (a key nuclear lamina protein) and H3K9me2 (a histone modification enriched at the nuclear periphery) in mouse ESCs and ESC-derived cardiac myocytes. The observations of these experiments, within the context of the study, indicate that changes in the organization of key genes and cell-type specific genes occurs during cardiogenesis.

ORGANISM(S): Mus musculus

PROVIDER: GSE97877 | GEO | 2017/10/12

SECONDARY ACCESSION(S): PRJNA383301

REPOSITORIES: GEO

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