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Molecular Mediators of Cardiac Pathology in Cardiorenal Syndrome Type 4

ABSTRACT: We report the changes in left ventricle mRNA and miRNA abundance in response to 5/6 nephrectomy surgery This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE97950 | GEO | 2017/05/04

SECONDARY ACCESSION(S): PRJNA385338

REPOSITORIES: GEO

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Molecular Mediators of Cardiac Pathology in Cardiorenal Syndrome Type 4 [mRNA]

Project description:We report the changes in left ventricle mRNA abundance in response to 5/6 nephrectomy surgery

2017-05-04 | GSE98520 | GEO

Molecular Mediators of Cardiac Pathology in Cardiorenal Syndrome Type 4 [miRNA]

Project description:We report the changes in left ventricle miRNA abundance in response to 5/6 nephrectomy surgery

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Molecular Mediators of Cardiac Pathology in Cardiorenal Syndrome Type 4 [anti-miR-21]

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Cardiorenal Effects of Peritoneal Dialysis in the 5/6Nx Uremic Rat Model

Project description:In this study we compare transcriptomic changes in the kidney and left ventricle in response to peritoneal dialyisis exchanges performed 3x per day for 8 days beginning 6 weeks after 5/6 nephrectomy or sham surgery in 10 week old male Sprague Dawley rats. .

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Molecular Mediators of Cardiac Pathology in Cardiorenal Syndrome Type 4

Project description:Molecular Mediators of Cardiac Pathology in Cardiorenal Syndrome Type 4

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Expression data from murine cardiac fibroblasts and endothelial cells following Transverse Aortic Constriction

Project description:Accumulation of activated cardiac fibroblasts plays a key role in heart failure progression. These cells deposit excessive extracellular matrix that leads to mechanical stiffness, myocyte uncoupling and ischemia. To investigate whether two developmentally distinct cardiac fibroblast populations exhibit distinct expression profiles in response to cardiac injury, and therefore might necessitate distinct therapeutic targeting, we performed microarray analysis on FACS sorted cells. Tie2cre lineage traced CFs, non Tie2cre lineage traced cardiac fibroblasts and endothelial cells were isolated from left ventricle of SHAM operated and banded hearts at the onset of fibrosis, one week after surgery. We used microarrays to detail the global programme of gene expression in cardiac fibroblasts and endothelium following pressure overload. Tie2cre lineage traced, non-tie2cre lineage traced fibroblasts and endothelial cells were sorted from left ventricle of 3 SHAM operated and 3 TAC operated adult male Black Swiss mice. Tie2cre lineage traced, non-tie2cre lineage traced fibroblasts and endothelial cells were sorted from left ventricle of 3 SHAM operated and 3 Transaortic Constriction (TAC) operated adult male Black Swiss mice for RNA extraction and Affymetrix microarray analysis. Hypertrophy in TAC animals, an lack of hypertrophy in SHAM operated animals, was evaluated by hemodynamic measurements before surgery and one week after surgery. Cells were isolated one week after surgery.

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Differentially Expressed piRNAs in TAC-induced mouse cardiac hypertrophy

Project description:To systematically investigate the potential role of piRNA(s) and for the identification of specific piRNA(s) dysregulated in cardiac hypertrophy, we examined the global expression profile of piRNAs in left ventricle samples obtained 4 weeks after TAC surgery in adult mice.

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