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Sequencing of ponatinib-resistant LC-2/ad derivatives (PR1 and PR2) and parental LC-2/ad cells

ABSTRACT: Sequencing of ponatinib-resistant LC-2/ad derivatives (PR1 and PR2) and parental LC-2/ad cells was performed in order to determine mechanisms of acquired resistance in the PR1 and PR2 cell lines. NRAS p.Q61K mutation identified in PR1 cells. Upregulation of wild-type EGFR signaling identified in PR2 cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE98030 | GEO | 2017/04/21

SECONDARY ACCESSION(S): PRJNA383725

REPOSITORIES: GEO

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