Transcriptomics

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Gene expression in non-adherent MDA-MB-468 subpopulation


ABSTRACT: Plasticity between adhesive and less-adhesive states is important for mammalian cell behaviour. To investigate adhesion plasticity, we have selected a stable isogenic subpopulation of MDA-MB-468 breast carcinoma cells which grows in suspension. These suspension cells are unable to re-adhere to various matrices or to contract three-dimensional collagen lattices. By transcriptome analysis, we aimed to identified the determinants of adhesion plasticity, and found downregulation of the focal adhesion protein tensin3 (Tns3).

ORGANISM(S): Homo sapiens

PROVIDER: GSE98062 | GEO | 2017/04/22

SECONDARY ACCESSION(S): PRJNA383848

REPOSITORIES: GEO

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