Loss of Dnmt3a Immortalizes Hematopoietic Stem Cells in vivo [RNA-Seq]
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ABSTRACT: Recent epidemiological studies have shown that cancer-associated DNMT3A mutations can be detected in the blood of a large proportion of asymptotic elderly individuals. It is important to understand how these mutations provide a competitive advantage to HSCs and allow them to establish clonal dominance. Here we demonstrate that the stress of serial HSC transplantation immortalizes Dnmt3a-null HSCs.
ORGANISM(S): Mus musculus
PROVIDER: GSE98184 | GEO | 2018/04/25
REPOSITORIES: GEO
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