Transcriptome signature of WT and C3ar1-/-C5ar1-/- splenic DCs in response to CpG
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ABSTRACT: Our group showed that DC-instrinsic C3ar1/C5ar1 signals are required for TLR-initiated DC maturation in vivo. To more broadly analyze how local complement signaling affects DC maturation process in response to TLR9 stimulation, WT or C3ar1-/-C5ar1-/- mice were stimulated with CpG (i.v. 100 micrograms) or vehicle control. 4hrs later, splenic CD11c+DCs were isolated and RNAs from the cells were purified for microarray analyses.
ORGANISM(S): Mus musculus
PROVIDER: GSE98315 | GEO | 2017/04/29
SECONDARY ACCESSION(S): PRJNA384705
REPOSITORIES: GEO
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