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Constitutive and Tamoxifen inducible knockout of HDAC1 and HDAC2 in Microglia

ABSTRACT: Hdac1 and 2 are important regulators of developmental processes. In this study we created microglia specific compound Hdac1 and Hdac2 knock out mice. Pre-natal ablation of both Hdac1 and 2 from microglia leads to reduced cell number and altered cell morphology. To investigate how Hdac1 and 2 knock out in microglia alters cellular gene expression profile we carried out RNA-seq analysis at different time points.

ORGANISM(S): Mus musculus

PROVIDER: GSE98822 | GEO | 2018/03/14

REPOSITORIES: GEO

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