Transcriptomics

Dataset Information

0

Gene Expression Analysis of Melanoma Cells Treated with 6-Thio-dG In Vitro


ABSTRACT: Telomerase promoter mutations are highly prevalent in human tumors including melanoma. Telomere transcriptional signatures are enriched in a subset of therapy-naïve melanomas associated with worse overall survival, in BRAF-mutant intrinsically resistant melanoma cells that evade MAPK inhibitors (MAPKi), as well as in a subset of post-treatment tumor biopsies derived from patients who have disease progression on MAPKi or the immune checkpoint inhibitors, anti-CTLA-4 or anti-PD1. We demonstrate the efficacy of a telomerase-directed nucleoside, 6-thio-2'-deoxyguanosine (6-thio-dG) that results in telomere dysfunction and cell death in various models of therapy-resistant cells. Furthermore, 6-thio-dG significantly inhibits tumor growth of primary tumor biopsy cultures derived from patients who had disease progression on multiple therapies including anti-CTLA-4 or anti-PD1.

ORGANISM(S): Homo sapiens

PROVIDER: GSE99552 | GEO | 2017/06/02

SECONDARY ACCESSION(S): PRJNA388966

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2018-01-30 | GSE109821 | GEO
2023-06-07 | GSE219108 | GEO
2021-09-13 | GSE180874 | GEO
2021-09-13 | GSE160619 | GEO
2016-03-18 | GSE78220 | GEO
| 2385375 | ecrin-mdr-crc
| phs001493 | dbGaP
2024-05-06 | PXD052036 |
2023-03-08 | GSE223110 | GEO
2022-12-31 | E-MTAB-11729 | biostudies-arrayexpress