Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Gene expression profiles of multiple myeloma plasma cell fractions from bone marrow

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE99636 | GEO | 2018/09/27

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Gene expression profiles of multiple myeloma plasma cell fractions from bone marrow II

Project description:Today’s diagnostic tests for multiple myeloma (MM) reflect the criteria of the updated WHO classification based on biomarkers and clinicopathologic heterogeneity. To that end, we propose a new subtyping of myeloma plasma cells (PC) by B-cell subset associated gene signatures (BAGS), from the normal B-cell hierarchy in the bone marrow (BM). To do this, we combined FACS and GEP data from normal BM samples to generate classifiers by BAGS for the PreBI, PreBII, immature (Im), naïve (N), memory (M) and PC subsets. The resultant tumor assignments in available clinical datasets exhibited similar BAGS subtype frequencies in four cohorts across 1302 individual cases. The prognostic impact of BAGS was analyzed in patients treated with high dose melphalan as first line therapy in three prospective trials: UAMS, HOVON65/GMMG-HD4 and MRC Myeloma IX with Affymetrix U133 plus 2.0 microarray data available from diagnostic myeloma PC samples. The BAGS subtypes were significantly associated with progression free (PFS) and overall survival (OS) (PFS, P=3.05e−06 and OS, P=1.06e−11) in a meta-analysis of 926 pts. The major impact was observed within the PreBII and M subtypes conferred with significant inferior prognosis compared to the Im, N and PC subtypes. Cox proportional hazard meta-analysis documented that the BAGS subtypes added significant and independent prognostic information to the TC classification system and ISS staging. BAGS subtype analysis identified transcriptome differences and a number of novel differentially spliced genes. We have identified hierarchal subtype differences in the myeloma plasma cells, with prognostic impact. This observation support an acquired reversible B-cell trait and phenotypic plasticity as a hallmark, also in MM.

2018-09-27 | GSE99635 | GEO

Gene expression profiles of multiple myeloma plasma cell fractions from bone marrow I

2018-09-27 | GSE99634 | GEO

Gene expression profiles of multiple myeloma plasma cell fractions from bone marrow III

2018-09-27 | GSE107843 | GEO

Bone Marrow Stroma-induced Transcriptome and Regulome Signatures of Multiple Myeloma

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-02-13 | GSE193658 | GEO

Identifying a high-risk cellular signature in the multiple myeloma bone marrow microenvironment

Project description:This SuperSeries is composed of the SubSeries listed below.

2019-08-31 | GSE136400 | GEO

Gene expression profiles of multiple myeloma plasma cell fractions from bone marrow

Project description:Gene expression profiles of multiple myeloma plasma cell fractions from bone marrow

| PRJNA389119 | ENA

Bone Marrow Stromal Cell Induced Chromatin Remodeling and Associated Transcriptional Changes in Multiple Myeloma

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-02-25 | GSE220144 | GEO

Gene expression profiles of multiple myeloma plasma cell fractions from bone marrow III

Project description:Gene expression profiles of multiple myeloma plasma cell fractions from bone marrow III

| PRJNA421668 | ENA

Roles of Iron in Chemoresistance of Multiple Myeloma Depends on the Interaction with Bone Marrow Stromal Cells

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-10-07 | GSE214768 | GEO

IRF4 requires ARID1A to establish plasma cell identity in multiple myeloma

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-05-01 | GSE253716 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data