Methylation profiling

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MeDIP-sequencing of shSRC-1 and shNT tamoxifen treated LY2 cells


ABSTRACT: The steroid co-activator protein SRC-1 plays an important role in endocrine therapy resistant breast cancer. Its expression is associated with large high grade tumours, HER2 positivity, disease recurrence and resistance to endocrine therapy. While SRC-1 typically functions to activate gene expression, some evidence has pointed towards a potential role in repression. This study looks into the effects of a stable knockdown of SRC-1 in a tamoxifen resistant cell line, LY2, and the effects of this knock down on the methylation landscape.

ORGANISM(S): Homo sapiens

PROVIDER: GSE99648 | GEO | 2018/06/04

REPOSITORIES: GEO

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