Transcriptomics

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Molecular pathogenesis of human prostate basal cell hyperplasia reveals a keratinocyte metaplasia


ABSTRACT: The incidence of basal cell hyperplasia (BCH) has been reported at 8-10%, but a molecular and cellular characterization has not been performed on this phenotype. Using freshly digested tissue from surgical specimens, we performed transcriptomic analysis of flow cytometry-purified basal epithelia from patients with and without a majority BCH phenotype. Gene set enrichment analysis revealed an increased expression of members of the epidermal differentiation complex, resembling the progression of other metaplastic diseases.

ORGANISM(S): Homo sapiens

PROVIDER: GSE99824 | GEO | 2017/07/12

SECONDARY ACCESSION(S): PRJNA389735

REPOSITORIES: GEO

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