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GNPS Theonella swinhoei (yellow chemotype) and Entotheonella enriched cell fractions

ABSTRACT: UPLC-MS/MS or nanoLC-MS/MS data acquired from whole sponge extracts from the marine sponge Theonella swinhoei (yellow chemotype; Hachijo Jima, Japan) or extracts from two Entotheonella enriched cell fractions obtained by differential centrifugation. More than 40 bioactive polyketides and modified peptides that belong to seven structural classes are known to be produced by this sponge. Single-cell genomics and chemical analysis have revealed Entotheonella as the producer of most of the known chemistry from this sponge. Reference: Wilson MC, Mori T, R�ckert C, Uria AR, Helf MJ, Takada K, Gernert C, Steffens UA, Heycke N, Schmitt S, Rinke C, Helfrich EJ, Brachmann AO, Gurgui C, Wakimoto T, Kracht M, Cr�semann M, Hentschel U, Abe I, Matsunaga S, Kalinowski J, Takeyama H, Piel J, An environmental bacterial taxon with a large and distinct metabolic repertoire. Nature. 2014 Feb 6;506(7486):58-62.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Hachijo Jima, Japan) And Entotheonella Enriched Cell Fractions Theonella Swinhoei (yellow Chemotype

SUBMITTER: Piel

PROVIDER: MSV000078670 | GNPS | Fri May 23 09:47:00 BST 2014

REPOSITORIES: GNPS

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Project description:This study corresponds to a re-analysis and meta-analysis of the five transcriptomic studies related to spontaneous tolerance to renal allograft in human. It examines the transcriptome of peripheral blood samples from six distinct clinical groups: healthy volunteers (HV); tolerant patients (TOL); stable patients on minimal immunosuppression (MIS) or maintained on classical immunosuppressive therapy (STA); patients showing either signs of chronic rejection (CR) or acute rejection (AR). The initial studies are the following: -Study 1 from Braud C. et al. (J Cell Biochem., 2008) published under GEO accession number GSE47755 and comprising 250 unique samples (8 HV; 21 TOL; 190 STA; 31 CR). -Study 2 from Brouard S. et al. (Proc Natl Acad Sci U S A., 2007) published under GEO accession number GSE47683 and comprising 67 unique samples (8 HV; 12 TOL; 10 MIS; 12 STA; 11 CR; 14 AR). - Study 3 from Lozano JJ. et al. (Am J Transplant., 2011) published under GEO accession number GSE22707 and comprising 42 unique samples (6 HV; 12 TOL; 12 STA; 12 CR). - Study 4 from Newell KA. et al. (J Clin Invest., 2010) published under GEO accession number GSE22229 and comprising 58 unique samples (12 HV; 19 TOL; 27 STA). - Study 5 from Sagoo P. et al. (J Clin Invest. 2010) published under GEO accession number GSE14655 and comprising two distinct cohorts of patients. The IOT (“Indices of Tolerance”) cohort (5a) corresponds to a European group of patients and totalizes 74 unique samples (8 HV; 10 TOL; 11 MIS; 36 STA; 9 CR). The ITN (“Immune Tolerance in Transplantation”) cohort (5b) corresponds to an American group of patients and totalizes 105 unique samples (20 HV; 22 TOL; 11 MIS; 34 STA; 18 CR). The final data matrix corresponds to the combination of the data from the five independent studies and examines the expression of 1846 meta-genes (MG) across 596 unique blood samples. The 1846 meta-genes correspond to the genes being measured across the five datasets and form a virtual microarray platform (TOL-HUMAN-G1846). The 596 examined samples can be divided into 62 HV, 96 TOL, 32 MIS, 311 STA, 81 CR, and 14 AR.

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GNPS Theonella swinhoei (yellow chemotype) and Entotheonella enriched cell fractions

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