Metabolomics

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GNPS-Duncan et al. Chem Biol 2015 Salinispora dataset

ABSTRACT: 35 Salinispora strains were grown in A1 and extracted with ethyl acetate.

INSTRUMENT(S): 6520A Quadrupole Time-of-Flight LC/MS

ORGANISM(S): Salinispora Arenicola (ncbitaxon:168697) Salinispora Tropica (ncbitaxon:168695) Salinispora Pacifica (ncbitaxon:351187)

SUBMITTER: Jensen/Moore 

PROVIDER: MSV000079284 | GNPS | Mon Aug 31 04:20:00 BST 2015

REPOSITORIES: GNPS

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Molecular networking and pattern-based genome mining improves discovery of biosynthetic gene clusters and their products from Salinispora species.

Duncan Katherine R KR   Crüsemann Max M   Lechner Anna A   Sarkar Anindita A   Li Jie J   Ziemert Nadine N   Wang Mingxun M   Bandeira Nuno N   Moore Bradley S BS   Dorrestein Pieter C PC   Jensen Paul R PR  

Chemistry & biology 20150409 4

Genome sequencing has revealed that bacteria contain many more biosynthetic gene clusters than predicted based on the number of secondary metabolites discovered to date. While this biosynthetic reservoir has fostered interest in new tools for natural product discovery, there remains a gap between gene cluster detection and compound discovery. Here we apply molecular networking and the new concept of pattern-based genome mining to 35 Salinispora strains, including 30 for which draft genome sequen  ...[more]

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