Dataset Information
GNPS - Effect of HDAC inhibition on metabolome of Aspergillus nidulans and discovery of many aspercryptins
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Aspergillus Nidulans Fgsc A4 (ncbitaxon:227321)
SUBMITTER: Neil Kelleher
PROVIDER: MSV000079900 | GNPS | Mon Jul 11 15:24:00 BST 2016
REPOSITORIES: GNPS
Publications
Large-scale metabolomics reveals a complex response of Aspergillus nidulans to epigenetic perturbation.
ACS chemical biology 20150403 6
The microbial world offers a rich source of bioactive compounds for those able to sift through it. Technologies capable of quantitatively detecting natural products while simultaneously identifying known compounds would expedite the search for new pharmaceutical leads. Prior efforts have targeted histone deacetylases in fungi to globally activate the production of new secondary metabolites, yet no study has directly assessed its effects with minimal bias at the metabolomic level. Using untargete ...[more]
